Endoplasmic reticulum and the microRNA environment in the cardiovascular system 1.

A new interesting article has been published in Can J Physiol Pharmacol. 2019 Jun;97(6):515-527. doi: 10.1139/cjpp-2018-0720. Epub 2019 May 7. and titled:

Endoplasmic reticulum and the microRNA environment in the cardiovascular system 1.

Authors of this article are:

Groenendyk J, Fan X, Peng Z, Kurgan L, Michalak M.

A summary of the article is shown below:

Stress responses are important to human physiology and pathology, and the inability to adapt to cellular stress leads to cell death. To mitigate cellular stress and re-establish homeostasis, cells, including those in the cardiovascular system, activate stress coping response mechanisms. The endoplasmic reticulum, a component of the cellular reticular network in cardiac cells, mobilizes so-called endoplasmic reticulum stress coping responses, such as the unfolded protein response. MicroRNAs play an important part in the maintenance of cellular and tissue homeostasis, perform a central role in the biology of the cardiac myocyte, and are involved in pathological cardiac function and remodeling. In this paper, we review a link between endoplasmic reticulum homeostasis and microRNA with an emphasis on the impact on stress responses in the cardiovascular system.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: ER stress; cœur; endoplasmic reticulum; heart; microRNA; réponse UPR; réticulum endoplasmique; stress du RE; unfolded protein response.