Graphene oxide-L-arginine nano-gel: a pH-sensitive fluorouracil nanocarrier.

A new interesting article has been published in Biotechnol Appl Biochem. 2019 May 22. doi: 10.1002/bab.1768. and titled:

Graphene oxide-L-arginine nano-gel: a pH-sensitive fluorouracil nanocarrier.

Authors of this article are:

Malekimusavi H, Ghaemi A, Masoudi G, Chogan F, Rashedi H, Yazdian F, Omidi M, Javadi S, Haghiralsadat BF, Teimouri M, Faal Hamedani N.

A summary of the article is shown below:

Nowadays, putting forward an accurate cancer therapy method with minimal side effects is an important topic of research. Nanostructures, for their ability in controlled and targeted drug release on specific cells, are critical materials in this field. In this study, a pH-sensitive graphene oxide- L-arginine nanogel was synthesized to carry and release 5-fluorouracil (5-FU). Optimized condition by statistical analysis, based on the maximum relative viscosity of nano-gel was evaluated 5.489 for the concentration of L-arginine and 2.404 for pH. The prepared nanogels were characterized using SEM and TEM images, and FTIR analysis. Cytotoxicity was assessed using the SRB assay on MCF-7 breast cancer cells. The fluorouracil release was measured by the dialysis bag method, UV spectrophotometry and fluorouracil calibration diagram. Results proved the successful controlled release of fluorouracil at pH = 5.4 and the beneficial role of graphene-oxide- L-arginine- fluorouracil nanogel in eliminating cancer cells.This article is protected by copyright. All rights reserved.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: L-arginine; drug delivery; fluorouracil; graphene-oxide; nanogel.