Probing the ligand preferences of the three types of bacterial pantothenate kinase.
Authors of this article are:
Guan J, Barnard L, Cresson J, Hoegl A, Chang JH, Strauss E, Auclair K.
A summary of the article is shown below:
Pantothenate kinase (PanK) catalyzes the transformation of pantothenate to 4′-phosphopantothenate, the first committed step in coenzyme A biosynthesis. While numerous pantothenate antimetabolites and PanK inhibitors have been reported for bacterial type I and type II PanKs, only a few weak inhibitors are known for bacterial type III PanK enzymes. Here, a series of pantothenate analogues were synthesized using convenient synthetic methodology. The compounds were exploited as small organic probes to compare the ligand preferences of the three different types of bacterial PanK. Overall, several new inhibitors and substrates were identified for each type of PanK.
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This article is a good source of information and a good way to become familiar with topics such as:
Antimetabolites;Coenzyme A;PanK;Pantothenate kinase;Pantothenate kinase inhibitors
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