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[Andrological consultation in new systemic oncological therapies with small molecules].

A new interesting article has been published in Hautarzt. 2018 Dec;69(12):984-990. doi: 10.1007/s00105-018-4299-y. English ; Review and titled:

[Andrological consultation in new systemic oncological therapies with small molecules].

Authors of this article are:

Weidner T, Paasch U, Grunewald S.

A summary of the article is shown below:

Small molecules are rapidly broadening the spectrum of systemic oncologic therapies. Targets of those drugs are-among others-tyrosine and serine/threonine kinases like VEGF-R, EGF-R, Bcr-Abl, c‑kit, JAK, CDK as well as BRAF and MEK. Clinical data of potential risks to male fertility are still very limited and are generally only available for older preparations. In addition, they are often multikinase inhibitors, so that even small molecules with the same (main) target are not completely comparable. For fertility protection, sperm cryopreservation should be offered to men seeking fatherhood before starting targeted therapy.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

Cryopreservation;Fertility;Gonadotoxicity;Sperm;Targeted therapy

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