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A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction.

A new interesting article has been published in Trends Pharmacol Sci. 2018 Dec;39(12):1008-1020. doi: 10.1016/j.tips.2018.10.007. Epub 2018 Oct 29. Review and titled:

A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction.

Authors of this article are:

Borroto-Escuela DO, Wydra K, Filip M, Fuxe K.

A summary of the article is shown below:

The concept of allosteric receptor-receptor interactions in G protein-coupled receptor homo- and heteroreceptor complexes in which they physically interact provides a new dimension to molecular integration in the brain. The receptor-receptor interactions dynamically change recognition, pharmacology, signaling, and trafficking of the participating receptors. Among the receptor complexes, disruption of the A2A receptor-dopamine D2 receptor (A2AR-D2R) complex by an A2AR agonist has been shown to fully block the inhibition of cocaine self-administration. Cocaine induced pathological A2AR-D2R-Sigma1R complexes may form a long-term memory with a strong and permanent D2R brake, leading to cocaine addiction. These heteroreceptor complexes can potentially be targeted for future pharmacotherapy of cocaine addiction by using heterobivalent compounds or A2AR-D2R receptor interface-interfering peptides that disrupt the A2AR-D2R-Sigma1R complexes.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

addiction;cocaine self-administration;heteroreceptor complexes;long-term memory;receptor–receptor interactions

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