Science News

The mTOR Independent Function of Tsc1 and FNIPs.

A new interesting article has been published in Trends Biochem Sci. 2018 Dec;43(12):935-937. doi: 10.1016/j.tibs.2018.09.018. Epub 2018 Oct 22. and titled:

The mTOR Independent Function of Tsc1 and FNIPs.

Authors of this article are:

Sager RA, Woodford MR, Mollapour M.

A summary of the article is shown below:

New roles for Tsc1 and FNIP1/2 as regulators of the molecular chaperone Hsp90 were recently identified, demonstrating a broader cellular impact outside of AMPK-mTOR signaling. In studying the function of these proteins we must take a holistic view of the cell, instead of maintaining our focus on a single pathway.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

Birt-Hogg-Dubé syndrome;Hsp90;co-chaperone;mTOR;tuberous sclerosis complex

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