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Muscle-derived stem cells: important players in peripheral nerve repair.

A new interesting article has been published in Expert Opin Ther Targets. 2018 Dec;22(12):1009-1016. doi: 10.1080/14728222.2018.1539706. Epub 2018 Oct 28. and titled:

Muscle-derived stem cells: important players in peripheral nerve repair.

Authors of this article are:

Musavi L, Brandacher G, Hoke A, Darrach H, Lee WPA, Kumar A, Lopez J.

A summary of the article is shown below:

Stem cell therapy for peripheral nerve repair is a rapidly evolving field in regenerative medicine. Although most studies to date have investigated stem cells originating from bone marrow or adipose, skeletal muscle has recently been recognized as an abundant and easily accessible source of stem cells. Muscle-derived stem cells (MDSCs) are a diverse population of multipotent cells with pronounced antioxidant and regenerative capacity. Areas covered: The current literature on the various roles MDSCs serve within the micro- and macro-environment of nerve injury. Furthermore, the exciting new research that is establishing MDSC-cellular therapy as an important therapeutic modality to improve peripheral nerve regeneration. Expert opinion: MDSCs are a promising therapeutic agent for the repair of peripheral nerves; MDSCs not only undergo gliogenesis and angiogenesis, but they also orchestrate larger pro-regenerative host responses. However, the isolation, transformation, and in-vivo behavior of MDSCs require further evaluation prior to clinical application.

Check out the article’s website on Pubmed for more information:

This article is a good source of information and a good way to become familiar with topics such as:

Schwann cells;Stem cell therapy;muscle-derived stem cells;nerve regeneration;peripheral nerve repair


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