Genetic Profiles for Systemic Lupus Erythematosus in Han Chinese Population: From Genome-Wide Association Study to Exome-Wide Association Study.
Authors of this article are:
Wen L, Liu L, Xue K, Cui Y.
A summary of the article is shown below:
Systemic lupus erythematosus (SLE) is a chronic heterogeneous autoimmune disease characterized by loss of tolerance to self-antigens, complement activation, dysregulated type 1 IFN responses, and immune-mediated tissue damage. The clinical features of SLE are pleomorphic, affecting virtually any organ system, such as skin, joints, central nervous system, or kidneys. Currently, the etiology and pathogenesis of SLE are not fully understood. Generally, it is considered that genetic factors, immune abnormalities, sex hormones, and environmental factors are associated with SLE, and mainly caused by genetic and environmental interactions, typical for a complex disease with multiple susceptibility genes. Therefore, identification of SLE susceptibility loci through molecular genetics methods may help build the foundation for identifying individuals and groups susceptible to SLE, early prevention, new drug development, and individualized treatment promoting precision medicine.
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