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The MYC Enhancer-ome: Long-Range Transcriptional Regulation of MYC in Cancer.

A new interesting article has been published in Trends Cancer. 2018 Dec;4(12):810-822. doi: 10.1016/j.trecan.2018.10.003. Epub 2018 Nov 2. Review and titled:

The MYC Enhancer-ome: Long-Range Transcriptional Regulation of MYC in Cancer.

Authors of this article are:

Lancho O, Herranz D.

A summary of the article is shown below:

MYC is one of the most important oncogenes in cancer. Indeed, MYC is upregulated in 50-60% of all tumors. MYC overexpression can be achieved through a variety of mechanisms, including gene duplications, chromosomal translocations, or somatic mutations leading to increased MYC stability. However, recent studies have identified numerous tissue-specific noncoding enhancers of MYC that play major roles in cancer, highlighting long-range transcriptional regulation of MYC as a critical novel mechanism leading to MYC hyperactivation and as a potential target for new therapeutic strategies in the near future. Here we summarize the regions and mechanisms involved in the long-range transcriptional regulation of MYC, underscoring the relevance of MYC enhancers both in normal physiological development and in MYC-driven cancer initiation and progression.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

MYC;SNP;cancer;enhancer;long-range transcriptional regulation

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