Science News

Invasive monitoring after resection of epileptogenic neocortical lesions in multistaged epilepsy surgery in children.

A new interesting article has been published in Epilepsy Res. 2018 Dec;148:48-54. doi: 10.1016/j.eplepsyres.2018.09.001. Epub 2018 Sep 19. and titled:

Invasive monitoring after resection of epileptogenic neocortical lesions in multistaged epilepsy surgery in children.

Authors of this article are:

Hidalgo ET, Frankel HG, Rodriguez C, Orillac C, Phillips S, Patel N, Devinsky O, Friedman D, Weiner HL.

A summary of the article is shown below:

OBJECTIVE: Incomplete resection of neocortical epileptogenic foci correlates with failed epilepsy surgery in children. We often treat patients with neocortical epilepsy with a staged approach using invasive monitoring to localize the focus, resect the seizure onset zone, and, in select cases, post-resection invasive monitoring (PRM). We report the technique and the outcomes of children treated with staged surgery including PRM.METHODS: We retrospectively reviewed the charts of pediatric patients with neocortical epilepsy who underwent resective surgery with PRM.RESULTS: We identified 71 patients, 5 patients with MRI-negative epilepsy and 66 patients with MRI-identified neocortical lesions; 64/66 (97%) patients had complete lesionectomy. In 61/71 (86%) patients PRM was associated with positive outcomes. Those findings were: 1) clinical seizures with electrographic involvement at resection margins (47%); 2) subclinical seizures and interictal discharges at resection margins (29%); and 3) clinical and subclinical seizures revealing a new epileptogenic focus (20%). In 55/71 (77%) patients, PRM data led to additional resection (re-resection; RR). Six additional patients had no further resection due to overlap with eloquent cortex. Histopathology showed tuberous sclerosis complex (TSC; n = 46), focal cortical dysplasia (FCD; n = 16)), gliosis (n = 4), tumors (n = 4), and Sturge-Weber syndrome (n = 1). There were no major complications. Seizure-free outcome in children with TSC was 63% at 1-year follow-up and 56% at 2-year follow-up. In FCD, seizure freedom after 1 and 2 years was 85%.SIGNIFICANCE: Post-resection monitoring may provide additional information about the extent of the epileptogenic zone, such as residual epileptogenic activity at the margins of the resection cavity, and may unmask additional seizure foci. This method may be especially useful in achieving long-term stable seizure-free outcome.Copyright © 2018 Elsevier B.V. All rights reserved.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

Invasive monitoring;Long-term outcome;Pediatric epilepsy surgery;Post-resection invasive monitoring;Resection

.

Categories: Science News