Science News

A Systematic Review of Molecular Autopsy Studies in Sudden Infant Death Cases.

A new interesting article has been published in J Pediatr Genet. 2018 Dec;7(4):143-149. doi: 10.1055/s-0038-1668079. Epub 2018 Aug 18. Review and titled:

A Systematic Review of Molecular Autopsy Studies in Sudden Infant Death Cases.

Authors of this article are:

Heathfield LJ, Martin LJ, Ramesar R.

A summary of the article is shown below:

Sudden unexpected death is an upsetting event, which can remain unexplained even after post-mortem investigation. Internationally, molecular autopsies have shown to resolve up to 44% of unexplained cases; however, it is currently unclear how many of these were infants. This systematic literature review showed that significantly fewer infant cases were resolved (median: 4%) compared with cohorts of 1 to 45 years old (median: 32%). Further, no study involving indigenous African participants has yet been published. Overall, molecular autopsies hold immense value to living family members and is motivation to explore new avenues in infant cohorts.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

medico-legal investigation;negative autopsy;sudden infant death syndrome

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