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New triterpenoids from Staphylea bumalda flower buds and their neuroprotective activity against H2O2-induced injury in vitro.

A new interesting article has been published in Arch Pharm Res. 2018 Dec;41(12):1162-1169. doi: 10.1007/s12272-018-1086-3. Epub 2018 Oct 30. and titled:

New triterpenoids from Staphylea bumalda flower buds and their neuroprotective activity against H2O2-induced injury in vitro.

Authors of this article are:

Zhang ZX, Feng K, Sui XJ, Wang WS, Wang L, Wang DH, Luo XM, Chen XF.

A summary of the article is shown below:

Four new acylated triterpene glycosides with aliphatic chains (4-7) as well as five known triterpenoids were isolated from the flower buds of Staphylea bumalda with bioassay guidance. Their structures were determined on the basis of spectral techniques, including IR, 1D and 2D NMR, and HR-APCI-MS. Most compounds (except 8) were isolated from S. bumalda for the first time. Additionally, the neuroprotective effects of 1 and 4-9 on suckling rat primary cultured hippocampal neurons against H2O2-induced injury were evaluated in vitro. The four new triterpenoids (4-7) showed neuroprotective effects, which increased the cell viability to over 74% at different concentrations, which was higher than the negative control (59%), while compounds 1 and 8-9 exhibited cytotoxic activity.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

Acylated triterpene glycosides;Neuroprotective activity;Staphylea bumalda;Staphyleaceae

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