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Awakening the Bowman: inhibition of CXCL12 signaling activates parietal epithelial cells.

A new interesting article has been published in Kidney Int. 2018 Dec;94(6):1042-1044. doi: 10.1016/j.kint.2018.09.011. and titled:

Awakening the Bowman: inhibition of CXCL12 signaling activates parietal epithelial cells.

Authors of this article are:

Massa F, Schedl A.

A summary of the article is shown below:

Glomerular podocytes are terminally differentiated cells, and podocyte loss is a common feature of progressive renal pathologies. In this issue, Romoli et al. focus on podocyte progenitors that were proposed to reside in the Bowman’s capsule. They demonstrate that suppression of CXCL12/CXCR4 signaling activates parietal epithelial cells that integrate into glomeruli, express podocyte specific markers, and interdigitate with existing cells. The data may open new therapeutic avenues for the treatment of glomerular diseases.

Check out the article’s website on Pubmed for more information:



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