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SNW1 as a novel transcriptional regulator of the NF-κB pathway.

A new interesting article has been published in Mol Cell Biol. 2018 Nov 5. pii: MCB.00415-18. doi: 10.1128/MCB.00415-18. [Epub ahead of print] and titled:

SNW1 as a novel transcriptional regulator of the NF-κB pathway.

Authors of this article are:

Verma S, De Jesus P, Chanda SK, Verma IM.

A summary of the article is shown below:

The nuclear factor-kappa B (NF-κB) family of transcription factors plays a central role in coordinating the expression of genes that control inflammation, immune responses, cell-proliferation, and a variety of other biological processes. In an attempt to identify novel regulators of this pathway, we performed whole-genome RNAi screens in physiologically relevant human macrophages in response to Lipopolysaccharides and Tumor Necrosis Factor Alpha. The top hit was SNW1, a splicing factor and transcriptional co-activator.

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