Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors.
Authors of this article are:
Liu Y, Wang Y, Chakroff J, Johnson J, Farrell A, Besner GE.
A summary of the article is shown below:
This study compared side-by-side the impact of donor age on the production of tissue-engineered small intestine (TESI). Each age represents a specific period of life: E18 for fetuses, 5-day-old pups for neonates, 21-day-old rats for weanlings, and 6-week-old rats for adults. The TESI produced was compared macroscopically and microscopically. The mechanism(s) contributing to the differences observed was explored by detecting proliferating cells in the TESI and by analyzing intestinal stem cell gene expression in donor cells. These data may provide valuable information for future application of TESI clinically.
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This article is a good source of information and a good way to become familiar with topics such as:
donor age;intestinal stem cells;tissue maturation;tissue-engineered small intestine
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