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Development of and Recent Advances in Pd-Catalyzed Decarboxylative Asymmetric Protonation.

A new interesting article has been published in J Org Chem. 2018 Nov 6. doi: 10.1021/acs.joc.8b02478. [Epub ahead of print] and titled:

Development of and Recent Advances in Pd-Catalyzed Decarboxylative Asymmetric Protonation.

Authors of this article are:

Kingston C, James J, Guiry PJ.

A summary of the article is shown below:

Decarboxylative asymmetric protonation (DAP) is a mild and efficient synthetic tool for the catalytic asymmetric formation of tertiary stereocenters adjacent to a carbonyl group. The development of the methodology from the initial racemic report to recent asymmetric examples is summarized. The discovery of an enantiodivergent Pd-catalyzed DAP, in which the choice of the achiral proton source determines the stereochemical outcome, is highlighted. Furthermore, the mechanism of Pd-catalyzed DAP, investigated since the initial report, is also discussed.

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