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An overview of epigenetic agents and natural nutrition products targeting DNA methyltransferase, histone deacetylases and microRNAs.

A new interesting article has been published in Food Chem Toxicol. 2018 Nov 5. pii: S0278-6915(18)30791-9. doi: 10.1016/j.fct.2018.10.052. [Epub ahead of print] Review and titled:

An overview of epigenetic agents and natural nutrition products targeting DNA methyltransferase, histone deacetylases and microRNAs.

Authors of this article are:

Huang D, Cui L, Ahmed S, Zainab F, Wu Q, Wang X, Yuan Z.

A summary of the article is shown below:

Several humans’ diseases such as; cancer, heart disease, diabetes retain an etiology of epigenetic, and a new therapeutic option termed as “epigenetic therapy” can offer a potential way to treat these diseases. A numbers of epigenetic agents such as; inhibitors of DNA methyltransferase (DNMT) and histone deacetylases (HDACs) have grew an intensive investigation, and many of these agents are currently being tested in a clinical trial, while some of them have been approved for the use by the authorities. Since miRNAs can act as tumor suppressors or oncogenes, the miRNA mimics and molecules targeted at miRNAs (antimiRs) have been designed to treat some of the diseases. Much naturally occurring nutrition were discovered to alter the epigenetic states of cells. The nutrition, including polyphenol, flavonoid compounds, and cruciferous vegetables possess multiple beneficial effects, and some can simultaneously change the DNA methylation, histone modifications and expression of microRNA (miRNA). This review mainly summarizes the information of epigenetic agents of DNMTs and HDACs inhibitors, miRNA mimics and antimiRs, as well as the natural nutrition. In addition, some future perspectives related to the epigenetic therapy are also included.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

DNA methylation;DNMT;Epigenetic therapy;HDAC;Histone modifications;microRNA

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