Effects of Moderate Cycling Exercise on Blood Glucose Regulation Following Successful Clinical Islet Transplantation.
Authors of this article are:
Yardley JE,, Rees JL, Funk DR, Toghi-Eshghi SR, Boulé NG, Senior PA.
A summary of the article is shown below:
Context: Islet transplantation is effective in preventing hypoglycemia in individuals with type 1 diabetes (T1D). However, it is currently unknown whether transplanted islets regulate plasma glucose concentrations appropriately during and after exercise in human islet transplant recipients (ITx).Objective: To determine the effect of exercise on plasma glucose, insulin, and glucagon concentrations in ITx compared to individuals without diabetes (CON).Intervention: Participants completed two conditions in random order, 1) 45 minutes of aerobic exercise (60% VO2peak), and 2) 45 minutes of seated rest. Blood samples were drawn at baseline, immediately post-exercise/rest, and every 15 minutes throughout a 60-minute recovery period. Post-exercise (24 hours) interstitial glucose was monitored using continuous glucose monitors.Results: Twenty-four participants (12 ITx, 12 CON) completed the protocol. Plasma glucose decreased more over time with exercise in ITx compared to CON [main effects of treatment (p=0.019), time (p=0.001) and group (p=0.012)]. Plasma glucose was lower during exercise versus rest in ITx, but not CON [treatment by group interaction (p=0.028)]. Plasma glucose decreased more during exercise versus the rest session [treatment by time interaction (p=0.001)]. One ITx and one CON experienced plasma glucose concentrations <3.5 mmol/L at the end of exercise, both of whom returned above that threshold within 15 minutes. Nocturnal CGM glucose below 3.5 mmol/L was detected in two CON, but no ITx.Conclusion: Despite a greater plasma glucose decline during exercise in ITx, hypoglycemia risk was similar during and following exercise in ITx compared to CON.
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