Morphological classification of melanoma metastasis with reflectance confocal microscopy.
Authors of this article are:
Farnetani F, Manfredini M, Longhitano S, Chester J, Kaleci S, Cinotti E, Mazzoni L, Venturini M, Manganoni A, Longo C, Bonnetti LR, Giannetti L, Rubegni P, Calzavara-Pinton P, Stanganelli I, Perrot JL0, Pellacani G.
A summary of the article is shown below:
BACKGROUND: Cutaneous malignant melanoma metastases differential diagnosis is challenging, as clinical and dermoscopic features can simulate primary melanoma or other benign or malignant skin neoplasms, and in-vivo reflectance confocal microscopy could assist. Our aim was to identify specific reflectance confocal microscopy features for cutaneous malignant melanoma metastases, and epidermal and dermal involvement.METHODS: A retrospective, multicenter observational study of lesions with proven cutaneous malignant melanoma metastases diagnosis between January 2005 and December 2016. Lesions were retrospectively assessed according to morphological features observed at reflectance confocal microscopy. Potential homogeneous subgroups of epidermal or dermal involvement were investigated with cluster analysis.RESULTS: Cutaneous malignant melanoma metastases (51 lesions in 29 patients) exhibited different frequencies of features according to metastasis dermoscopy patterns. Lesions classified at dermoscopy with nevus-like globular and non-globular patterns were more likely to be epidermotropic, showing characteristics of epidermal and dermal involvement and other dermoscopy pattern classifications were more likely to be dermotropic, in the majority of cases displaying diagnostic features. Distinguishing features at reflectance confocal microscopy included irregular (78%) and altered (63%) epidermis, pagetoid infiltration (51%), disarranged junctional architecture (63%), non edged papillae (76%), dense and sparse, and cerebriform nests in the upper dermis (74%), and vascularity (51%). Cluster analysis identified 3 groups, which were retrospectively correlated with histopathological diagnoses of dermotropic and epidermotropic diagnoses (p<0.001). The third cluster represents lesions with deep dermis morphological changes, which were too deep for evaluation with reflectance confocal microscopy.CONCLUSIONS: Specific reflectance confocal microscopy features of cutaneous malignant melanoma metastases for correct diagnosis, and subtype diagnosis, seems achievable in most cases where morphological alterations are located above the deep dermis. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
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This article is a good source of information and a good way to become familiar with topics such as:
dermoscopy;malignant melanoma;metastasis;reflectance confocal microscopy
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