[EXPRESS] Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional p…
Authors of this article are:
Shubayev V, Strongin A, Yaksh T.
A summary of the article is shown below:
Complex regional pain syndrome (CRPS) is an extremely painful condition that develops after trauma to a limb. CRPS exhibits autoimmune features in part mediated by autoantibodies against muscarinic-2 acetylcholine (M2) receptor. The mechanisms underlying the M2 receptor involvement in CRPS remain obscure. Based on our recent work demonstrating that limb nerve trauma releases a potent proalgesic, immunodominant myelin basic protein (MBP) fragment, our present sequence database analyses reveal an unexpected and previously undescribed structural homology of the proalgesic MBP fragment with the M2 receptor. As both CRPS and the proalgesic MBP activity are prevalent in females, this MBP/M2 homology presents an inviting hypothesis explaining the mechanisms of autoimmune pathogenesis and sexual dimorphism that underlies vulnerability toward developing CRPS and other pain states with neuropathic features. This hypothesis may aid in the development of novel diagnostic and therapeutic strategies to chronic pain.
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