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Differentiation of triple-negative breast cancer from other subtypes through whole-tumor histogram analysis on multiparametric MR imaging.

A new interesting article has been published in Eur Radiol. 2018 Nov 6. doi: 10.1007/s00330-018-5804-5. [Epub ahead of print] and titled:

Differentiation of triple-negative breast cancer from other subtypes through whole-tumor histogram analysis on multiparametric MR imaging.

Authors of this article are:

Xie T, Zhao Q, Fu C, Bai Q, Zhou X, Li L, Grimm R, Liu L, Gu Y, Peng W.

A summary of the article is shown below:

PURPOSE: To identify triple-negative (TN) breast cancer imaging biomarkers in comparison to other molecular subtypes using multiparametric MR imaging maps and whole-tumor histogram analysis.MATERIALS AND METHODS: This retrospective study included 134 patients with invasive ductal carcinoma. Whole-tumor histogram-based texture features were extracted from a quantitative ADC map and DCE semi-quantitative maps (washin and washout). Univariate analysis using the Student’s t test or Mann-Whitney U test was performed to identify significant variables for differentiating TN cancer from other subtypes. The ROC curves were generated based on the significant variables identified from the univariate analysis. The AUC, sensitivity, and specificity for subtype differentiation were reported.RESULTS: The significant parameters on the univariate analysis achieved an AUC of 0.710 (95% confidence interval [CI] 0.562, 0.858) with a sensitivity of 63.6% and a specificity of 73.1% at the best cutoff point for differentiating TN cancers from Luminal A cancers. An AUC of 0.763 (95% CI 0.608, 0.917) with a sensitivity of 86.4% and a specificity of 72.2% was achieved for differentiating TN cancers from human epidermal growth factor receptor 2 (HER2) positive cancers. Also, an AUC of 0.683 (95% CI 0.556, 0.809) with a sensitivity of 54.5% and a specificity of 83.9% was achieved for differentiating TN cancers from non-TN cancers. There was no significant feature on the univariate analysis for TN cancers versus Luminal B cancers.CONCLUSIONS: Whole-tumor histogram-based imaging features derived from ADC, along with washin and washout maps, provide a non-invasive analytical approach for discriminating TN cancers from other subtypes.KEY POINTS: • Whole-tumor histogram-based features on MR multiparametric maps can help to assess biological characterization of breast cancer. • Histogram-based texture analysis may predict the molecular subtypes of breast cancer. • Combined DWI and DCE evaluation helps to identify triple-negative breast cancer.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

Classification;Immunologic subtyping;Magnetic resonance imaging;ROC curve;Triple-negative breast cancer

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