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Metal-free synthesis of fulleropyrrolidin-2-ols: a novel reaction of [60]fullerene with amines and 2,2-disubstituted acetaldehydes.

A new interesting article has been published in Org Biomol Chem. 2018 Nov 7;16(41):7648-7656. doi: 10.1039/c8ob01903g. Epub 2018 Oct 4. and titled:

Metal-free synthesis of fulleropyrrolidin-2-ols: a novel reaction of [60]fullerene with amines and 2,2-disubstituted acetaldehydes.

Authors of this article are:

Huang G, Zhang M, Wang HJ, Li FB, Yang F, Liu L, Liu CY, Asiri AM, Alamry KA.

A summary of the article is shown below:

A series of scarce fulleropyrrolidin-2-ols were synthesized by the facile one-step reaction of [60] fullerene with inexpensive and readily accessible amines and 2,2-disubstituted acetaldehydes without the addition of valuable metal salts in moderate yields, comparable to those for most monoadducts reported previously. This strategy exhibits a broad substrate scope and excellent functional group tolerance. A plausible reaction pathway for the formation of fulleropyrrolidin-2-ols is proposed to elucidate the above reaction process.

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