Circulating S100A8/A9 Levels Reflect Intraocular Inflammation in Uveitis Patients.
Authors of this article are:
Wang YQ, Dai XD, Ran Y, Cao Y, Lan CL, Guan JT, Liu C, Yang FM, Gan YJ, Liu BJ, Fang AW, Lin D, Gong XH, Cui RZ, Jin ZB, Qu J, Lu F, Chi ZL.
A summary of the article is shown below:
PURPOSE: To investigate whether there is an association between circulating S100A8/A9 levels and uveitis activity.METHODS: A total of 549 plasma samples were collected from uveitis patients and non-uveitic controls.RESULTS: S100A8/A9 plasma levels were elevated in uveitis patients compared to non-uveitic controls (P < 0.001). S100A8/A9 plasma levels in patients with active acute anterior uveitis (AAU) were significantly elevated and remarkably decreased in parallel with the severity of intraocular inflammation after corticosteroid treatment (P < 0.001). S100A8/A9 plasma levels were also higher in AAU patients with ankylosing spondylitis (AS) than in patients without AS (P = 0.02). S100A8/A9 plasma levels were significantly increased in uveitis patients with elevated C-reactive protein (CRP, P = 0.004) or erythrocyte sedimentation rates (ESR, P = 0.049) levels compared to uveitis patients with normal CRP or ESR values.CONCLUSION: Circulating S100A8/A9 might be a useful biomarker for the measurement of intraocular inflammation.
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