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Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes.

A new interesting article has been published in Clin Sci (Lond). 2018 Nov 6. pii: CS20180690. doi: 10.1042/CS20180690. [Epub ahead of print] and titled:

Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes.

Authors of this article are:

Mahapatra G, Smith SC, Hughes TM, Wagner B, Maldjian JA, Freedman BI, Molina AJA.

A summary of the article is shown below:

Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In this study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with longstanding Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes.  Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

bioenergetics;diabetes;mitochondria;neuroimaging

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