An intracellular diamine oxidase triggered hyperpolarized 129Xe magnetic resonance biosensor.
Authors of this article are:
Zhang B, Guo Q, Luo Q, Zhang X, Zeng Q, Zhao L, Yuan Y, Jiang W, Yang Y, Liu M, Ye C, Zhou X.
A summary of the article is shown below:
Here, a novel method was developed for suppressing 129Xe signals in cucurbituril (CB6) until the trigger is activated by a specific enzyme. Due to its noncovalent interactions with amino-groups and CB6, putrescine dihydrochloride (Put) was chosen for blocking interactions between 129Xe and CB6. Upon adding diamine oxidase (DAO), Put was released from CB6 and a 129Xe@CB6 Hyper-CEST signal emerged. This proposed 129Xe biosensor was then tested in small intestinal villus epithelial cells.
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