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An intracellular diamine oxidase triggered hyperpolarized 129Xe magnetic resonance biosensor.

A new interesting article has been published in Chem Commun (Camb). 2018 Nov 6. doi: 10.1039/c8cc07822j. [Epub ahead of print] and titled:

An intracellular diamine oxidase triggered hyperpolarized 129Xe magnetic resonance biosensor.

Authors of this article are:

Zhang B, Guo Q, Luo Q, Zhang X, Zeng Q, Zhao L, Yuan Y, Jiang W, Yang Y, Liu M, Ye C, Zhou X.

A summary of the article is shown below:

Here, a novel method was developed for suppressing 129Xe signals in cucurbit[6]uril (CB6) until the trigger is activated by a specific enzyme. Due to its noncovalent interactions with amino-groups and CB6, putrescine dihydrochloride (Put) was chosen for blocking interactions between 129Xe and CB6. Upon adding diamine oxidase (DAO), Put was released from CB6 and a 129Xe@CB6 Hyper-CEST signal emerged. This proposed 129Xe biosensor was then tested in small intestinal villus epithelial cells.

Check out the article’s website on Pubmed for more information:



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