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α-Fetoprotein Influence on the Conversion of Naïve T-Helpers into Memory T-Cell Effector Subpopulations.

A new interesting article has been published in Dokl Biol Sci. 2018 Sep;482(1):210-213. doi: 10.1134/S0012496618050113. Epub 2018 Nov 6. and titled:

α-Fetoprotein Influence on the Conversion of Naïve T-Helpers into Memory T-Cell Effector Subpopulations.

Authors of this article are:

Zamorina SA, Timganova VP, Bochkova MS, Khramtsov PV, Fomicheva KA, Rayev MB,, Chereshnev VA.

A summary of the article is shown below:

The effect of native α-fetoprotein (AFP) on the conversion of naïve T-helpers into central memory T-cells (TCM) and effector subpopulations of the preterminally differentiated (TEM) and terminally differentiated (TEMRA) memory T-cells was studied. AFP was found to prevent the conversion of naïve T-helpers into effector subpopulations of memory T cells (TEM and TEMRA) while reducing the total production of IL-4 and IFN-γ by the studied cell populations. The data reveal a new role of AFP in the immune tolerance formation during pregnancy.

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