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Guiding recombinant antivenom development by omics technologies.

A new interesting article has been published in N Biotechnol. 2018 Oct 25;45:19-27. doi: 10.1016/j.nbt.2017.05.005. Epub 2017 May 24. Review and titled:

Guiding recombinant antivenom development by omics technologies.

Authors of this article are:

Laustsen AH.

A summary of the article is shown below:

In this review, the different approaches that have been employed with the aim of developing novel antivenoms against animal envenomings are presented and discussed. Reported efforts have focused on the use of innovative immunization strategies, small molecule inhibitors against enzymatic toxins, endogenous animal proteins with toxin-neutralizing capabilities, and recombinant monoclonal antibodies. Harnessing either of these approaches, antivenom development may benefit from an in-depth understanding of venom compositions and the medical importance of individual venom toxins. Focus is thus also directed towards the different omics technologies (particularly venomics, antivenomics, and toxicovenomics) that are being used to uncover novel animal toxins, shed light on venom complexity, and provide directions for how to determine the medical relevance of individual toxins within whole venoms. Finally, techniques for assessing antivenom specificity and cross-reactivity are reviewed, with special focus on antivenomics and high-density peptide microarray technology.

Check out the article’s website on Pubmed for more information:

This article is a good source of information and a good way to become familiar with topics such as:

Animal envenomings;Antivenomics;High-density peptide microarray technology;Omics technologies;Recombinant antivenom;Snakebite;Toxicovenomics;Venomics


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