Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster.
Authors of this article are:
Harbison ST,, Kumar S, Huang W,, McCoy LJ, Smith KR, Mackay TFC.
A summary of the article is shown below:
Circadian rhythms influence physiological processes from sleep-wake cycles to body temperature and are controlled by highly conserved cycling molecules. Although the mechanistic basis of the circadian clock has been known for decades, the extent to which circadian rhythms vary in nature and the underlying genetic basis for that variation is not well understood. We measured circadian period (Ʈ) and rhythmicity index in the Drosophila Genetic Reference Panel (DGRP) and observed extensive genetic variation in both. Seven DGRP lines had sexually dimorphic arrhythmicity and one line had an exceptionally long Ʈ. Genome-wide analyses identified 584 polymorphisms in 268 genes. We observed differences among transcripts for nine genes predicted to interact among themselves and canonical clock genes in the long period line and a control. Mutations/RNAi knockdown targeting these genes also affected circadian behavior. Our observations reveal that complex genetic interactions influence high levels of variation in circadian phenotypes.
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This article is a good source of information and a good way to become familiar with topics such as:
Circadian rhythms;Drosophila melanogaster;Genome-wide association;Period;Rhythmicity index
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