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Comparative Analysis of Long Noncoding RNAs Expressed During Intramuscular Adipocytes Adipogenesis in Fat-type and Lean-type Pigs.

A new interesting article has been published in J Agric Food Chem. 2018 Oct 19. doi: 10.1021/acs.jafc.8b04243. [Epub ahead of print] and titled:

Comparative Analysis of Long Noncoding RNAs Expressed During Intramuscular Adipocytes Adipogenesis in Fat-type and Lean-type Pigs.

Authors of this article are:

Sun Y, Chen X, Qin J, Liu S, Zhao R, Yu T, Chu G, Yang G, Wei-Jun P.

A summary of the article is shown below:

The meat quality of local breed pigs is more tender and juicier than the imported varieties. The important reason is that the intramuscular fat content is high. Even though modest sequence conservation and evolution, the expression pattern and function of long non-coding RNAs (lncRNAs) seem to be conserved. In spite of that, analysis of lncRNAs associated with intramuscular fat development remains unknown to us in porcine. Here, we systematically investigated lncRNAs of intramuscular adipocytes of fat local Bamei pig and lean Large White pig to consider the function of lncRNAs on intramuscular fat development. We selected three piglets of both breeds separately to isolate intramuscular preadipocytes and performed RNA sequencing across four stages (0, 2, 4 and 8 d) during the intramuscular preadipocytes differentiation, and identified 1932 lncRNAs (760 novel). In addition, we have screened lnc_000414 closely related to fat synthesis. This lncRNA function as an inhibitor in the proliferation of porcine intramuscular adipocytes. These novel findings will provide new targets for improving pork quality and making pig breeding better.

Check out the article’s website on Pubmed for more information:



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