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Cobalt-Catalyzed Hydroboration of Alkenes, Aldehydes, and Ketones.

A new interesting article has been published in Org Lett. 2018 Oct 19. doi: 10.1021/acs.orglett.8b02775. [Epub ahead of print] and titled:

Cobalt-Catalyzed Hydroboration of Alkenes, Aldehydes, and Ketones.

Authors of this article are:

Tamang SR, Bedi D, Shafiei-Haghighi S, Smith CR, Crawford C, Findlater M.

A summary of the article is shown below:

An operationally convenient and general method for hydroboration of alkenes, aldehydes, and ketones employing Co(acac)3 as a precatalyst is reported. The hydroboration of alkenes in the presence of HBpin, PPh3, and NaO tBu affords good to excellent yields with high Markovnikov selectivity with up to 97:3 branched/linear selectivity. Moreover, Co(acac)3 could be used effectively to hydroborate aldehydes and ketones in the absence of additives under mild reaction conditions. Inter- and intramolecular chemoselective reduction of the aldehyde group took place over the ketone functional group.

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