Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea.
Authors of this article are:
Sandargo B, Thongbai B, Praditya D, Steinmann E, Stadler M,0, Surup F.
A summary of the article is shown below:
4-Hydroxypleurogrisein, a congener of the anticancer-lead compound pleurotin, as well as six further derivatives were isolated from the basidiomycete Hohenbuehelia grisea, strain MFLUCC 12-0451. The structures were elucidated utilizing high resolution electron spray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectral data and evaluated for their biological activities; for leucopleurotin, we provide Xray data. While most congeners showed moderate antimicrobial and cytotoxic activity, 4-hydroxypleurogrisein emerged as an inhibitor of hepatitis C virus infectivity in mammalian liver cells.
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This article is a good source of information and a good way to become familiar with topics such as:
Basidiomycota;HCV;Hohenbuehelia grisea;Pleurotin;fungi;secondary metabolites;structure elucidation
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