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Synthesis of ( E)-β-Selenovinyl Sulfones through a Multicomponent Regio- and Stereospecific Selenosulfonation of Alkynes with Insertion of Sulfur D…

A new interesting article has been published in Org Lett. 2018 Oct 22. doi: 10.1021/acs.orglett.8b02733. [Epub ahead of print] and titled:

Synthesis of ( E)-β-Selenovinyl Sulfones through a Multicomponent Regio- and Stereospecific Selenosulfonation of Alkynes with Insertion of Sulfur D…

Authors of this article are:

Sun K, Shi Z, Liu Z, Luan B, Zhu J, Xue Y.

A summary of the article is shown below:

A novel and practical method for the selenosulfonation of alkynes with the insertion of sulfur dioxide has been developed. A series of β-(seleno)vinyl sulfones with high levels of regio- and stereoselectivity have been prepared. The key features of this reaction include a broad substrate scope, excellent functional-group tolerance, and amenability to scale-up synthesis. A plausible radical mechanism is proposed to illustrate this reaction.

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