Catalytic enantioselective ene-type reactions of vinylogous hydrazone: construction of α-methylene-γ-butyrolactone derivatives.
Authors of this article are:
Zhang H, Yao Q, Cao W, Ge S, Xu J, Liu X, Feng X.
A summary of the article is shown below:
The catalytic asymmetric ene-type reactions of vinylogous hydrazone were accomplished by using chiral N,N’-dioxide-metal salt complexes as catalysts. A wide range of electrophiles, including isatins, α-ketoester, imines, and aldehydes reacted with (E)-2-methyl-N-(piperidin-1-yl)prop-2-en-1-imine efficiently, affording the corresponding homoallylic alcohols and amines in high yields (up to 99%) with excellent ee values (up to 99%). The methodology provided a convenient way to synthesize bioactive chiral α-methylene-γ-butyrolactone derivatives.
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