HBV patients with low HBsAg and high HBcrAg titers have a high risk of HBV-related HCC.
Authors of this article are:
Suzuki Y, Maekawa S, Komatsu N, Sato M, Tatsumi A, Miura M, Matsuda S, Muraoka M, Nakakuki N, Shindo H, Amemiya F, Takano S, Fukasawa M, Nakayama Y, Yamaguchi T, Inoue T, Sato T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N.
A summary of the article is shown below:
BACKGROUND AND AIM: Although the viral markers HBsAg and HBcrAg may reflect intrahepatic hepatitis B virus (HBV) replication activity and may constitute important biomarkers for hepatocellular carcinoma (HCC), the value of using these two markers in combination for assessing the HCC risk has not been clarified in detail until now.PATIENTS AND METHODS: Four hundred and forty-nine consecutive patients with chronic HBV infection were included in the study and the association of HBsAg and HBcrAg with the HCC risk was investigated cross-sectionally, as well as longitudinally.RESULTS: When the high value cutoffs of HBsAg and HBcrAg were respectively defined as 3.0 LogIU/ml and 3.0 LogU/ml, patients with a history of HCC were found frequently in the low HBsAg group (p=0.002) and high HBcrAg group (p<0.001). When HBsAg and HBcrAg were combined, an HCC history was most frequent in the subset with low HBsAg and high HBcrAg, among the HBeAg negative patients (OR 7.83, p <0.001), irrespective of nucleos(t) ide analogue (NA) administration (NA: OR 4.76, p <0.001, non-NA: OR 9.60, p <0.001). In a longitudinal analysis of the subsequent development of HCC, carried out on the 338 patients without an HCC history at enrollment, HCC developed significantly more frequently in the low HBsAg/high HBcrAg group (p = 0.005).CONCLUSIONS: The low HBsAg/high HBcrAg value group is at high risk of developing HBV-related HCC, according to cross-sectional and longitudinal analysis, demonstrating that the combination of HBsAg and HBcrAg values is an excellent biomarker for assessing the HCC risk.This article is protected by copyright. All rights reserved.
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HBV;HBcrAg;HBsAg;HCC;Nucleot(s) ide analogue therapy
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