Science News

Apolipoprotein A-IV: a potential therapeutic target for atherosclerosis.

A new interesting article has been published in Prostaglandins Other Lipid Mediat. 2018 Oct 20. pii: S1098-8823(18)30107-2. doi: 10.1016/j.prostaglandins.2018.10.004. [Epub ahead of print] Review and titled:

Apolipoprotein A-IV: a potential therapeutic target for atherosclerosis.

Authors of this article are:

Peng J, Li XP.

A summary of the article is shown below:

Apolipoprotein A-IV is lipid-binding protein, which is synthesized by the intestine and secreted into mesenteric lymph. ApoA-IV is correlated with chylomicrons and high density lipoprotein, but a large portion is free-lipoprotein, in circulation. Studies showed that apoA-IV has anti-inflammatory and anti-oxidative properties, and is able to mediate reverse cholesterol transport, which suggest that it may has anti-atherosclerotic effects and be related to protection from atherosclerotic cardiovascular disease. This article focus on current studies and the possible anti-atherogenic mechanism related to apoA-IV, in order to provide a new therapeutic target for atherosclerotic cardiovascular diseases.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

Apolipoprotein A-IV;Atherosclerosis;Lipids;Mechanism

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