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Micro-fabricated packed metal gas preconcentrator for enhanced monitoring of ultralow concentration of isoprene.

A new interesting article has been published in J Chromatogr A. 2018 Oct 19;1572:27-36. doi: 10.1016/j.chroma.2018.08.058. Epub 2018 Aug 31. and titled:

Micro-fabricated packed metal gas preconcentrator for enhanced monitoring of ultralow concentration of isoprene.

Authors of this article are:

Han B, Wang H, Huang H, Liu T, Wu G, Wang J.

A summary of the article is shown below:

A novel non-silicon-based micro-preconcentration device, as a pretreatment component in a portable gas chromatography system, was developed for the preconcentration one of the trace volatile organic compounds (VOCs) in the exhaled gases, which is one typical biomarker for the chronic liver disease (CLD). The device was designed as an array of manifold-shaped rectangular metal micro-channels with flat dimensions of 16 mm × 12.6 mm and the internal empty volume is 14.4 μL on the copper substrate. Instead of the non-silicon fabrication process, the traditional laser etching technology (LET) was optimized to etch micro-channels, and vacuum diffusion welding (VDW) was applied to form internal channels. The fabricated chip was filled with Carbopack X adsorbent. In the testing, the metal gas preconcentrator (MGP) was installed in a commercial GC (gas chromatography) and nitrogen was used as carrier gas and desorbed gas. With the MPG, up to 352 of concentration factor can be achieved for 10 ppb isoprene. The developed MGP, which has advantages of high strength, low cost, good thermal conductivities, can potentially be used for non-invasive screening of advanced liver fibrosis by monitoring isoprene concentrations in exhaled breath.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

Breath Tests;Butadienes;Chromatography, Gas;End Stage Liver Disease;Gases;Hemiterpenes;Humans;Lasers;Metals;Pentanes;Vacuum;Volatile Organic Compounds

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