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Salophen copper(II) complex-assisted click reactions for fast synthesis of 1,2,3-triazoles based on 1,4-naphthoquinone scaffold, anti-bacterial eva…

A new interesting article has been published in Chem Biodivers. 2018 Oct 20. doi: 10.1002/cbdv.201800410. [Epub ahead of print] and titled:

Salophen copper(II) complex-assisted click reactions for fast synthesis of 1,2,3-triazoles based on 1,4-naphthoquinone scaffold, anti-bacterial eva…

Authors of this article are:

Abbaspour S, Keivanloo A, Bakherad M, Sepehri S.

A summary of the article is shown below:

The salophen copper(II) complex was successfuly used for the efficient synthesis of new 1,2,3-triazoles based on the 1,4-naphthoquinone scaffold. The reaction of 2-chloro-3-(prop-2-yn-1-yloxy)-1,4-naphthoquinone or 2,3-bis(prop-2-yn-1-yloxy)-1,4-naphthoquinone with aromatic azides in the presence of a low copper catalyst loading (1 mol%) afforded 2-chloro-3-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)-1,4-naphthoquinone or 2,3-bis((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)-1,4-naphthoquinone, respectively. The advantages of these reactions are short reaction times, high-to-excellent reaction yields, operational simplicity, and mild experimental conditions. The new 1,2,3-triazoles obtained were screened for their in vitro anti-bacterial activities and were subjected to molecular docking studies.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

1,2,3-triazole;1,4-Naphthoquinone;Click reaction;anti-bacterial activity;molecular docking

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