Process Design and Optimisation in the Pharmaceutical Industry: a Suzuki-Miyaura Procedure for the Synthesis of Savolitinib.
Authors of this article are:
Adlington NK, Agnew LR, Campbell AD, Cox RJ, Dobson A, Fernandez Barrat C, Gall MAY, Hicks W, Howell GP, Jawor-Baczynska A, Miller-Potucka L, Pilling M, Shepherd K, Tassone R, Taylor BA, Williams A.
A summary of the article is shown below:
A multidisciplinary approach covering synthetic, physical and analytical chemistry, high-throughput experimentation and experimental design, process engineering and solid-state chemistry is used to develop a large-scale (kilomole) Suzuki-Miyaura process. Working against clear criteria and targets, a full process investigation and optimisation package is described highlighting how and why key decisions are made in the development of large-scale pharmaceutical processes.
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