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Process Design and Optimisation in the Pharmaceutical Industry: a Suzuki-Miyaura Procedure for the Synthesis of Savolitinib.

A new interesting article has been published in J Org Chem. 2018 Oct 23. doi: 10.1021/acs.joc.8b02351. [Epub ahead of print] and titled:

Process Design and Optimisation in the Pharmaceutical Industry: a Suzuki-Miyaura Procedure for the Synthesis of Savolitinib.

Authors of this article are:

Adlington NK, Agnew LR, Campbell AD, Cox RJ, Dobson A, Fernandez Barrat C, Gall MAY, Hicks W, Howell GP, Jawor-Baczynska A, Miller-Potucka L, Pilling M, Shepherd K, Tassone R, Taylor BA, Williams A.

A summary of the article is shown below:

A multidisciplinary approach covering synthetic, physical and analytical chemistry, high-throughput experimentation and experimental design, process engineering and solid-state chemistry is used to develop a large-scale (kilomole) Suzuki-Miyaura process. Working against clear criteria and targets, a full process investigation and optimisation package is described highlighting how and why key decisions are made in the development of large-scale pharmaceutical processes.

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