Epidemiologic and Genotypic distribution of Noroviruses among children with Acute Diarrhea and Healthy Controls in a Low-income Rural Setting.
Authors of this article are:
Hossain ME, Rahman R, Ali SI, Islam MM, Rahman MZ, Ahmed S, Faruque ASG, Barclay L, Vinjé J, Rahman M.
A summary of the article is shown below:
Background: Noroviruses are the most common cause of epidemic and endemic acute gastroenteritis (AGE) worldwide. The burden of norovirus disease in low-income settings is poorly understood.Methods: We tested stool samples from children less than 5 years of age with diarrhea who were admitted in a rural hospital in Bangladesh from 2010-2012 and from matched healthy controls from the same catchment area.Results: Norovirus was detected in 109 (18%) of 613 children with diarrhea and in 30 (15%) of 206 healthy controls. Most (n=118; 85%) norovirus infections belonged to genogroup II (GII). Of these, GII.4 viruses were identified in 36 (33%) of the cases and in 6 (21%) of the controls. Other major genotypes included GII.3 (13%), GII.6 (11%), and GII.13 (11%) in cases and GII.6 (17%) and GII.2 (14%) in controls. Greatest risk of severe norovirus disease (Vesikari score ≥11) was associated to GII.4 infections. GII.4 viruses were the predominant genotype detected during the winter (55%) and rainy season (23%) while GII.3 (19%) and GII.13 (19%) viruses were the most prevalent genotypes during the summer. Vomiting was significantly associated with GII.4 infection, while longer duration of diarrhea with GI.3 infection.Conclusions: Future studies are needed to understand the high rates of virus shedding in children without AGE symptoms.
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