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3D-Printed Carbon Electrodes for Neurotransmitter Detection.

A new interesting article has been published in Angew Chem Int Ed Engl. 2018 Oct 22;57(43):14255-14259. doi: 10.1002/anie.201809992. Epub 2018 Oct 4. and titled:

3D-Printed Carbon Electrodes for Neurotransmitter Detection.

Authors of this article are:

Yang C, Cao Q, Puthongkham P, Lee ST, Ganesana M, Lavrik NV, Venton BJ.

A summary of the article is shown below:

Implantable neural microsensors have significantly advanced neuroscience research, but the geometry of most probes is limited by the fabrication methods. Therefore, new methods are needed for batch-manufacturing with high reproducibility. Herein, a novel method is developed using two-photon nanolithography followed by pyrolysis for fabrication of free-standing microelectrodes with a carbon electroactive surface. 3D-printed spherical and conical electrodes were characterized with slow scan cyclic voltammetry (CV). With fast-scan CV, the electrodes showed low dopamine LODs of 11±1 nm (sphere) and 10±2 nm (cone), high sensitivity to multiple neurochemicals, and high reproducibility. Spherical microelectrodes were used to detect dopamine in a brain slice and in vivo, demonstrating they are robust enough for tissue implantation. This work is the first demonstration of 3D-printing of free-standing carbon electrodes; and the method is promising for batch fabrication of customized, implantable neural sensors.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

carbon;microelectrodes;neurotransmitters;sensors;two-photon lithography

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