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XLSY: Extra-Large NMR Spectroscopy.

A new interesting article has been published in Angew Chem Int Ed Engl. 2018 Oct 22;57(43):14043-14045. doi: 10.1002/anie.201806144. Epub 2018 Oct 1. and titled:

XLSY: Extra-Large NMR Spectroscopy.

Authors of this article are:

Pustovalova Y, Mayzel M, Orekhov VY.

A summary of the article is shown below:

NMR studies of intrinsically disordered proteins and other complex biomolecular systems require spectra with the highest resolution and dimensionality. An efficient approach, extra-large NMR spectroscopy, is presented for experimental data collection, reconstruction, and handling of very large NMR spectra by a combination of the radial and non-uniform sampling, a new processing algorithm, and rigorous statistical validation. We demonstrate the first high-quality reconstruction of a full seven-dimensional HNCOCACONH and two five-dimensional HACACONH and HN(CA)CONH experiments for a representative intrinsically disordered protein α-synuclein. XLSY will significantly enhance the NMR toolbox in challenging biomolecular studies.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

NMR spectroscopy;XLSY;intrinsically disordered protein;non-uniform sampling

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