Synthesis and self-assembly of Xylan-based amphiphiles: from bio-based vesicles to antifungal properties.
Authors of this article are:
Rosselgong J, Chemin M, Cabral Almada C, Hemery G, Guigner JM, Chollet G, Labat G, da Silva Perez D, Ham-Pichavant F, Grau E, Grelier S, Lecommandoux S, Cramail H.
A summary of the article is shown below:
This work aims at designing functional biomaterials through selective chemical modification of xylan from beechwood. Acidic hydrolysis of xylan leaded to well-defined oligomers with an average of six xylose units per chain and with an aldehyde group at the reductive end. Reductive amination was performed on this aldehyde end-group to introduce an azide reactive group. ‘Click chemistry’ was then applied to couple these hydrophilic xylans moieties with different hydrophobic fatty acid methyl esters that were previously functionalized with complementary alkyne functions. The resulting amphiphilic bio-based conjugates were then self-assembled using three different methods, namely direct solubilization, thin-film rehydration/extrusion and microfluidics. Well-defined micelles and vesicles were obtained and their high loading capacity with propiconazole as an antifungal active molecule was shown. The resulting vesicles loaded with propiconazole in a microfluidic process, proved to significantly improve the antifungal activity of propiconazole, demonstrating the high potential of such xylan-based amphiphiles.
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