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Lycodine type alkaloids from Lycopodiastrum casuarinoides with cytotoxic and cholinesterase inhibitory activities.

A new interesting article has been published in Fitoterapia. 2018 Oct 20. pii: S0367-326X(18)31729-5. doi: 10.1016/j.fitote.2018.10.021. [Epub ahead of print] and titled:

Lycodine type alkaloids from Lycopodiastrum casuarinoides with cytotoxic and cholinesterase inhibitory activities.

Authors of this article are:

Qu SM, Shan BH, Wang HT, Wang S.

A summary of the article is shown below:

A chemical investigation on the 70% EtOH extract of the aerial parts of Lycopodiastrum casuarinoides led to the isolation of six novel lycodine type alkaloids, lycocasuarines A-F (1-6). The structures of the isolated compounds were established based on 1D and 2D (1H1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated alkaloids were tested in vitro for cytotoxic potentials against seven malignant melanoma cell lines as well as acetylcholinesterase (AChE) and butyrocholinesterase (BuChE) inhibitory activities. As a result, alkaloids 1 and 3 exhibited significant cytotoxic activities against all the tested tumor cell lines with IC50 values <10 μM and the inhibitory activities for AchE (0.94 ± 0.15 and 0.24 ± 0.03 μM, respectively) and BuchE (1.82 ± 0.12 and 7.31 ± 0.42 μM, respectively).
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This article is a good source of information and a good way to become familiar with topics such as:

Cholinesterase;Cytotoxicity;Lycodine type alkaloids;Lycopodiaceae;Lycopodiastrum casuarinoides

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