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Bimetallic Rhodium(II)/Indium(III) Relay Catalysis for Tandem Insertion/Asymmetric Claisen Rearrangement.

A new interesting article has been published in Angew Chem Int Ed Engl. 2018 Oct 20. doi: 10.1002/anie.201810410. [Epub ahead of print] and titled:

Bimetallic Rhodium(II)/Indium(III) Relay Catalysis for Tandem Insertion/Asymmetric Claisen Rearrangement.

Authors of this article are:

Chen Y, Dong S, Xu X, Liu X, Feng X.

A summary of the article is shown below:

The first example of catalytic insertion/asymmetric Claisen rearrangement tandem reaction of N-sulfonyl-1,2,3-triazoles with allyl alcohol esters was achieved by bimetallic relay catalytic systems involving achiral rhodium salt and chiral N,N’-dioxide-indium(III) complex. This manifold could overcome the limitation of single RhII catalysis, providing a straight and facile route to various enantioenriched β/γ-amino acid derivatives in high yields (up to 99%) with excellent diastereo- and enantioselectivities (up to > 95:5 dr, 98:2 er). Moreover, possible transition state models were proposed to elucidate the origin of chiral induction based on the control experiments and X-ray crystal structure of the catalyst.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

asymmetric catalysis bimetal rearrangement tandem reaction 1,2,3-triazoles

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