Bimetallic Rhodium(II)/Indium(III) Relay Catalysis for Tandem Insertion/Asymmetric Claisen Rearrangement.
Authors of this article are:
Chen Y, Dong S, Xu X, Liu X, Feng X.
A summary of the article is shown below:
The first example of catalytic insertion/asymmetric Claisen rearrangement tandem reaction of N-sulfonyl-1,2,3-triazoles with allyl alcohol esters was achieved by bimetallic relay catalytic systems involving achiral rhodium salt and chiral N,N’-dioxide-indium(III) complex. This manifold could overcome the limitation of single RhII catalysis, providing a straight and facile route to various enantioenriched β/γ-amino acid derivatives in high yields (up to 99%) with excellent diastereo- and enantioselectivities (up to > 95:5 dr, 98:2 er). Moreover, possible transition state models were proposed to elucidate the origin of chiral induction based on the control experiments and X-ray crystal structure of the catalyst.
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asymmetric catalysis bimetal rearrangement tandem reaction 1,2,3-triazoles
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