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TARGETED ALPHA PARTICLE THERAPY FOR NEUROENDOCRINE TUMOURS: THE NEXT GENERATION OF PRRT .

A new interesting article has been published in Neuroendocrinology. 2018 Oct 23. doi: 10.1159/000494760. [Epub ahead of print] and titled:

TARGETED ALPHA PARTICLE THERAPY FOR NEUROENDOCRINE TUMOURS:
THE NEXT GENERATION OF PRRT
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Authors of this article are:

Grossman A, Navalkissoor S.

A summary of the article is shown below:

Neuroendocrine tumours (NETs) are being seen increasingly frequently, but to date only complete surgical resection is curative. However, among the various therapeutic options, peptide receptor radionuclide therapy (PRRT), linking a radioactive moiety to an octreotide derivative, has been shown to be highly efficacious and a well-tolerated therapy, improving progression-free survival and probably overall survival. Nevertheless, the current radionuclides in use are β-particle emitters with non-optimal radiobiological properties. A new generation of α-particle emitting radionuclides is being developed, with advantages in terms of very high energy and a short path length, which should theoretically show higher efficacy. We survey the current developments in this field, emphasising the exciting potential of this novel form of therapy for NETs.
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