Science News

The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid Chromatography.

A new interesting article has been published in Molecules. 2018 Oct 20;23(10). pii: E2709. doi: 10.3390/molecules23102709. and titled:

The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid Chromatography.

Authors of this article are:

Ismail OH, Felletti S, Luca C, Pasti L, Marchetti N, Costa V, Gasparrini F, Cavazzini A, Catani M.

A summary of the article is shown below:

Until less than 10 years ago, chiral separations were carried out with columns packed with 5 or 3 μ m fully porous particles (FPPs). Times to resolve enantiomeric mixtures were easily larger than 30 min, or so. Pushed especially by stringent requirements from medicinal and pharmaceutical industries, during the last years the field of chiral separations by liquid chromatography has undergone what can be defined a “true revolution”. With the purpose of developing ever faster and efficient method of separations, indeed, very efficient particle formats, such as superficially porous particles (SPPs) or.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as:

bioactive chiral compounds;supercritical fluid chromatography (SFC);ultra-high performance liquid chromatography (UHPLC);ultrafast enantioseparations

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