Mycoplasma genitalium Infections in Women Attending a Sexually Transmitted Disease Clinic in New Orleans.
Authors of this article are:
Lillis RA, Martin DH, Nsuami MJ.
A summary of the article is shown below:
Background: Several studies have reported statistically significant associations of Mycoplasma genitalium with cervicitis, urethritis, or vaginal discharge, although non-significant associations have also been reported. This study examined the associations of M. genitalium with selected sexually transmitted infections (STIs), demographic, behavioral, and clinical factors among women attending a sexually transmitted disease (STD) clinic in New Orleans.Methods: Women aged ≥18 years who presented to the New Orleans STD clinic provided sociodemographic data and sexual behavior, STI, obstetric and gynecologic history, along with urine, vaginal, endocervical, and rectal specimens. Specimens were tested for M. genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma hominis, Ureaplasma spp., and yeast. Bacterial vaginosis (BV) was diagnosed by Nugent score, and cervicitis was defined as ≥30 polymorphonuclear leukocytes per high power microscopic field on a cervical Gram stain or yellow mucopus on an endocervical swab.Results: Among 400 women studied, M. genitalium was independently significantly associated with age <25 years (P<0.03) and with ≥2 sexual partners in the last 12 months (P<0.003). N. gonorrhoeae (Adjusted odds ratio [AOR]: 1.75; P=0.103), C. trachomatis (AOR: 1.43; P=0.247), and T. vaginalis (AOR: 1.60; P=0.120), independently increased the odds of infection with M. genitalium. Controlling for other STIs and BV, there was a positive trend for M. genitalium to predict cervicitis (AOR: 3.18; 95% Confidence Interval: 0.99, 10.2; P=0.05).Conclusions: M. genitalium in our study displayed the clinical features of C. trachomatis and N. gonorrhoeae, the two organisms that drive research agendas in diagnosis, treatment, and prevention of bacterial STIs.
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