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Cascade Annulation of 2-Alkynylthioanisoles with Unsaturated α-Bromocarbonyls Leading to Thio-Benzobicyclic Skeletons.

A new interesting article has been published in J Org Chem. 2018 Oct 22. doi: 10.1021/acs.joc.8b02001. [Epub ahead of print] and titled:

Cascade Annulation of 2-Alkynylthioanisoles with Unsaturated α-Bromocarbonyls Leading to Thio-Benzobicyclic Skeletons.

Authors of this article are:

Gao Y, Zhang P, Li G, Zhao Y.

A summary of the article is shown below:

A protocol of Cu-catalyzed annulation of phenylethynylsulfanes with unsaturated α-bromocarbonyls for the construction of thio-benzobicyclic skeletons is described. In this single reaction, three new bonds and two new rings can be established, highlighting the step-economics and high efficiency of this protocol.

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