Proof of Concept for an Intracochlear Acoustic Receiver for Use in Acute Large Animal Experiments.
Authors of this article are:
Pfiffner F, Prochazka L, Dobrev I, Klein K, Sulser P, Péus D, Sim JH, Dalbert A, Röösli C, Obrist D0, Huber A.
A summary of the article is shown below:
(1) Background: The measurement of intracochlear sound pressure (ICSP) is relevant to obtain better understanding of the biomechanics of hearing. The goal of this work was a proof of concept of a partially implantable intracochlear acoustic receiver (ICAR) fulfilling all requirements for acute ICSP measurements in a large animal. The ICAR was designed not only to be used in chronic animal experiments but also as a microphone for totally implantable cochlear implants (TICI). (2) Methods: The ICAR concept was based on a commercial MEMS condenser microphone customized with a protective diaphragm that provided a seal and optimized geometry for accessing the cochlea. The ICAR was validated under laboratory conditions and using in-vivo experiments in sheep. (3) Results: For the first time acute ICSP measurements were successfully performed in a live specimen that is representative of the anatomy and physiology of the human. Data obtained are in agreement with published data from cadavers. The surgeons reported high levels of ease of use and satisfaction with the system design. (4) Conclusions: Our results confirm that the developed ICAR can be used to measure ICSP in acute experiments. The next generation of the ICAR will be used in chronic sheep experiments and in TICI.
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This article is a good source of information and a good way to become familiar with topics such as:
BioMEMS;acoustic receiver;auditory system;biomedical measurement;cochlea;ear;hydrophone;implantable microphone;implantable sensor;intracochlear sound pressure;sheep;totally implantable cochlear implant
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