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Expression profiles and prognostic value of miRNAs in retinoblastoma.

A new interesting article has been published in J Cancer Res Clin Oncol. 2018 Oct 22. doi: 10.1007/s00432-018-2773-7. [Epub ahead of print] Review and titled:

Expression profiles and prognostic value of miRNAs in retinoblastoma.

Authors of this article are:

Delsin LEA, Salomao KB, Pezuk JA, Brassesco MS.

A summary of the article is shown below:

Current cure rates for retinoblastoma (RB) are very high in developed countries. Nonetheless, in less privileged places worldwide, delayed diagnosis and refusal to adhere to treatment still endure an obstacle to improve overall patient survival. Thus, the access to consistent biomarkers for diagnosis at an earlier stage may facilitate treatment and improve outcomes. Over recent years, much attention has been focused on miRNAs, key post-transcriptional regulators that when altered, largely contribute to carcinogenesis and tumor progression. Many of the ~ 2500 microRNAs described in humans have shown differential expression profiles in tumors. In this review, we summarize current data about the roles of miRNAs in RB along with their value as diagnostic/prognostic factors using electronic databases such as PubMed. We reviewed the importance of miRNA in RB biology and discussed their implications in clinic intervention. Several miRNAs have pointed out reliable diagnostic and prognostic molecular biomarkers. The emergence of targeted therapies has significantly improved cancer treatment. In the near future, the modulation of miRNAs will represent a good treatment strategy.

Check out the article’s website on Pubmed for more information:

This article is a good source of information and a good way to become familiar with topics such as:

Cancer;Children;Retinoblastoma;Review;Solid tumor;miRNA


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